COVID-19 early treatment: real-time analysis of 4,131 studies
Analysis of 69 COVID-19 early treatments,
approvals in 105 countries, database of
7,568 treatments
Zhang | In Vitro study showing that the SARS-CoV-2 BA.2.87.1 lineage efficiently enters human cells but is more sensitive to neutralization by antibodies.. |
Ho | Review of quercetin and its derivatives for prevention and treatment of COVID-19. Authors discuss molecular docking evidence showing quercetin and.. |
Chacin-Bonilla | Review of the potential therapeutic effects of melatonin on viral infections, with a focus on SARS-CoV-2 and COVID-19. Authors highlight melatonin's.. |
Ochoa-Ramírez | Retrospective 292 COVID-19 patients finding that haplotype TC of the FokI and TaqI vitamin D receptor (VDR) gene polymorphisms was associated with.. |
Thomas | In Silico study showing that andrographolide derivatives (PubChem CID 2734589 and 138968421) are potential dual inhibitors of SARS-CoV-2.. |
Timeline for when studies showed efficacy - details and limitations.
0.6% of treatments show efficacy.
Treatment cost times median NNT - details and limitations.
0.6% of treatments show efficacy.
Loading..
All clinical results for selected treatments. 0.6% of treatments show efficacy.
Loading..
Random effects meta-analysis of all studies (pooled effects, all stages). Treatments with ≤3 studies with distinct authors or with <50 control events are shown in grey. Pooled results across all stages and outcomes depend on the distribution of stages and outcomes tested - for example late stage treatment may be less effective and if the majority of studies are late stage this may obscure the efficacy of early treatment. Please see the specific stage and outcome analyses. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.6% of proposed treatments show efficacy in clinical studies. | |||||
Loading.. Loading.. | |||||
Random effects meta-analysis of early treatment studies (pooled effects). Treatments with ≤3 studies with distinct authors or with <50 control events are shown in grey. Pooled results across all outcomes are affected by the distribution of outcomes tested, please see detail pages for specific outcome analysis. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.6% of proposed treatments show efficacy in clinical studies. | |||||
Loading.. Loading.. | |||||
Random effects meta-analysis of all mortality results (all stages). Treatments with ≤3 studies with distinct authors or with <25 control events are shown in grey. Pooled results across all stages depend on the distribution of stages tested - for example late stage treatment may be less effective and if the majority of studies are late stage this may obscure the efficacy of early treatment. Please see the specific stage analyses. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.6% of proposed treatments show efficacy in clinical studies. | |||||
Loading.. Loading.. | |||||
Random effects meta-analysis of early treatment mortality results. Treatments with ≤3 studies with distinct authors or with <25 control events are shown in grey. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.6% of proposed treatments show efficacy in clinical studies. | |||||
Loading.. Loading.. | |||||
Random effects meta-analysis of prophylaxis studies (pooled effects). Treatments with ≤3 studies with distinct authors or with <50 control events are shown in grey. Pooled results across all outcomes are affected by the distribution of outcomes tested, please see detail pages for specific outcome analysis. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.6% of proposed treatments show efficacy in clinical studies. | |||||
Loading.. Loading.. | |||||
Random effects meta-analysis of prophylaxis mortality results. Treatments with ≤3 studies with distinct authors or with <25 control events are shown in grey. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.6% of proposed treatments show efficacy in clinical studies. |
LATE TREATMENT | ||||||
Physician / Team | Location | Patients | HospitalizationHosp. | MortalityDeath | ||
Dr. David Uip (*) | Brazil | 2,200 | 38.6% (850) | Ref. | 2.5% (54) | Ref. |
EARLY TREATMENT - 40 physicians/teams | ||||||
Physician / Team | Location | Patients | HospitalizationHosp. | ImprovementImp. | MortalityDeath | ImprovementImp. |
Dr. Roberto Alfonso Accinelli 0/360 deaths for treatment within 3 days |
Peru | 1,265 | 0.6% (7) | 77.5% | ||
Dr. Mohammed Tarek Alam patients up to 84 years old |
Bangladesh | 100 | 0.0% (0) | 100.0% | ||
Dr. Oluwagbenga Alonge | Nigeria | 310 | 0.0% (0) | 100.0% | ||
Dr. Raja Bhattacharya up to 88yo, 81% comorbidities |
India | 148 | 1.4% (2) | 44.9% | ||
Dr. Flavio Cadegiani | Brazil | 3,450 | 0.1% (4) | 99.7% | 0.0% (0) | 100.0% |
Dr. Alessandro Capucci | Italy | 350 | 4.6% (16) | 88.2% | ||
Dr. Shankara Chetty | South Africa | 8,000 | 0.0% (0) | 100.0% | ||
Dr. Deborah Chisholm | USA | 100 | 0.0% (0) | 100.0% | ||
Dr. Ryan Cole | USA | 400 | 0.0% (0) | 100.0% | 0.0% (0) | 100.0% |
Dr. Marco Cosentino vs. 3-3.8% mortality during period; earlier treatment better |
Italy | 392 | 6.4% (25) | 83.5% | 0.3% (1) | 89.6% |
Dr. Jeff Davis | USA | 6,000 | 0.0% (0) | 100.0% | ||
Dr. Dhanajay | India | 500 | 0.0% (0) | 100.0% | ||
Dr. Bryan Tyson & Dr. George Fareed | USA | 20,000 | 0.0% (6) | 99.9% | 0.0% (4) | 99.2% |
Dr. Raphael Furtado | Brazil | 170 | 0.6% (1) | 98.5% | 0.0% (0) | 100.0% |
Rabbi Yehoshua Gerzi | Israel | 860 | 0.1% (1) | 99.7% | 0.0% (0) | 100.0% |
Dr. Heather Gessling | USA | 1,500 | 0.1% (1) | 97.3% | ||
Dr. Ellen Guimarães | Brazil | 500 | 1.6% (8) | 95.9% | 0.4% (2) | 83.7% |
Dr. Syed Haider | USA | 4,000 | 0.1% (5) | 99.7% | 0.0% (0) | 100.0% |
Dr. Mark Hancock | USA | 24 | 0.0% (0) | 100.0% | ||
Dr. Sabine Hazan | USA | 1,000 | 0.0% (0) | 100.0% | ||
Dr. Mollie James | USA | 3,500 | 1.1% (40) | 97.0% | 0.0% (1) | 98.8% |
Dr. Roberta Lacerda | Brazil | 550 | 1.5% (8) | 96.2% | 0.4% (2) | 85.2% |
Dr. Katarina Lindley | USA | 100 | 5.0% (5) | 87.1% | 0.0% (0) | 100.0% |
Dr. Ben Marble | USA | 150,000 | 0.0% (4) | 99.9% | ||
Dr. Edimilson Migowski | Brazil | 2,000 | 0.3% (7) | 99.1% | 0.1% (2) | 95.9% |
Dr. Abdulrahman Mohana | Saudi Arabia | 2,733 | 0.0% (0) | 100.0% | ||
Dr. Carlos Nigro | Brazil | 5,000 | 0.9% (45) | 97.7% | 0.5% (23) | 81.3% |
Dr. Benoit Ochs | Luxembourg | 800 | 0.0% (0) | 100.0% | ||
Dr. Ortore | Italy | 240 | 1.2% (3) | 96.8% | 0.0% (0) | 100.0% |
Dr. Valerio Pascua one death for a patient presenting on the 5th day in need of supplemental oxygen |
Honduras | 415 | 6.3% (26) | 83.8% | 0.2% (1) | 90.2% |
Dr. Sebastian Pop | Romania | 300 | 0.0% (0) | 100.0% | ||
Dr. Brian Proctor | USA | 869 | 2.3% (20) | 94.0% | 0.2% (2) | 90.6% |
Dr. Anastacio Queiroz | Brazil | 700 | 0.0% (0) | 100.0% | ||
Dr. Didier Raoult | France | 8,315 | 2.6% (214) | 93.3% | 0.1% (5) | 97.6% |
Dr. Karin Ried up to 99yo, 73% comorbidities, av. age 63 |
Turkey | 237 | 0.4% (1) | 82.8% | ||
Dr. Roman Rozencwaig patients up to 86 years old |
Canada | 80 | 0.0% (0) | 100.0% | ||
Dr. Vipul Shah | India | 8,000 | 0.1% (5) | 97.5% | ||
Dr. Silvestre Sobrinho | Brazil | 116 | 8.6% (10) | 77.7% | 0.0% (0) | 100.0% |
Dr. Unknown | Brazil | 957 | 1.7% (16) | 95.7% | 0.2% (2) | 91.5% |
Dr. Vladimir Zelenko | USA | 2,200 | 0.5% (12) | 98.6% | 0.1% (2) | 96.3% |
Mean improvement with early treatment protocols | 238,381 | HospitalizationHosp. | 94.4% | MortalityDeath | 94.9% |
Physician results with early treatment protocols compared to
no early treatment. These results are subject to selection and ascertainment
bias and more accurate analysis requires details of the patient populations
and followup, however results are consistently better across many teams, and consistent
with the extensive controlled trial evidence that shows a significant
reduction in risk with many early treatments, and improved results with the
use of multiple treatments in combination.
Zhang | In Vitro study showing that the SARS-CoV-2 BA.2.87.1 lineage efficiently enters human cells but is more sensitive to neutralization by antibodies.. |
Cokljat | Comparison of COVID-19 treatment guidelines from 109 countries with WHO guidelines, showing very high variation between national guidelines and.. |
Ho | Review of quercetin and its derivatives for prevention and treatment of COVID-19. Authors discuss molecular docking evidence showing quercetin and.. |
Nalban | In Silico study showing potential benefits of quercetin and other phytochemicals from Albizia lebbeck as SARS-CoV-2 main protease (Mpro) inhibitors... |
Zhou | In Silico study suggesting that quercetin and tetrandrine are potential treatments for COVID-19 and intrahepatic cholangiocarcinoma (ICC). Authors.. |
Chacin-Bonilla | Review of the potential therapeutic effects of melatonin on viral infections, with a focus on SARS-CoV-2 and COVID-19. Authors highlight melatonin's.. |
Ochoa-Ramírez | Retrospective 292 COVID-19 patients finding that haplotype TC of the FokI and TaqI vitamin D receptor (VDR) gene polymorphisms was associated with.. |
Jamilian | Meta analysis: 58% lower mortality (p=0.05) |
Thomas | In Silico study showing that andrographolide derivatives (PubChem CID 2734589 and 138968421) are potential dual inhibitors of SARS-CoV-2.. |
de Oliveira Só | In Silico study showing that ivermectin and nirmatrelvir interact with the SARS-CoV-2 main protease (Mpro). Authors used molecular docking and 100ns.. |
Scheim | Review of the biochemical underpinnings of the severe morbidities of COVID-19, focusing on the binding of the SARS-CoV-2 spike protein (SP) to.. |
Agamah | In Silico study identifying potential drugs beneficial for COVID-19 by integrating transcriptomics, proteomics, metabolomics, lipidomics, and drug.. |
de Oliveira Só | In Silico study showing that ivermectin and nirmatrelvir interact with the SARS-CoV-2 main protease (Mpro). Authors used molecular docking and 100ns.. |
Scheim | Review of the biochemical underpinnings of the severe morbidities of COVID-19, focusing on the binding of the SARS-CoV-2 spike protein (SP) to.. |
Scheim | Review of the biochemical underpinnings of the severe morbidities of COVID-19, focusing on the binding of the SARS-CoV-2 spike protein (SP) to.. |
Song | Meta analysis: 34% lower mortality (p<0.0001), 35% lower severe cases (p=0.002), and 23% lower hospitalization (p=0.02) |
Agamah | In Silico study identifying potential drugs beneficial for COVID-19 by integrating transcriptomics, proteomics, metabolomics, lipidomics, and drug.. |
Agamah | In Silico study identifying potential drugs beneficial for COVID-19 by integrating transcriptomics, proteomics, metabolomics, lipidomics, and drug.. |
Agamah | In Silico study identifying potential drugs beneficial for COVID-19 by integrating transcriptomics, proteomics, metabolomics, lipidomics, and drug.. |
Agamah | In Silico study identifying potential drugs beneficial for COVID-19 by integrating transcriptomics, proteomics, metabolomics, lipidomics, and drug.. |
Agamah | In Silico study identifying potential drugs beneficial for COVID-19 by integrating transcriptomics, proteomics, metabolomics, lipidomics, and drug.. |
Agamah | In Silico study identifying potential drugs beneficial for COVID-19 by integrating transcriptomics, proteomics, metabolomics, lipidomics, and drug.. |
Onozuka | RCT 90 low-risk asymptomatic to mildly symptomatic COVID-19 patients showing no significant difference in salivary viral load with cetylpyridinium.. |
Wang | Mendelian randomization study suggesting a causal association between retinol and related proteins (RBP4, RDH16, CRABP1) and COVID-19. The study.. |
Amani | Meta analysis of 13 studies involving 16,166 patients showing higher mortality and higher incidence of adverse events with molnupiravir compared.. |
Recent studies (see the individual treatment pages for all studies):
Apr 30 |
et al., Heliyon, doi:10.1016/j.heliyon.2024.e30080 | Therapeutic Implications of Quercetin and its Derived-products in COVID-19 Protection and Prophylactic |
Review of quercetin and its derivatives for prevention and treatment of COVID-19. Authors discuss molecular docking evidence showing quercetin and its derivatives can bind to multiple SARS-CoV-2 proteins including the main protease, spike.. | ||
Apr 29 |
et al., Therapeutic Innovation & Regulatory Science, doi:10.1007/s43441-024-00633-6 | The Effect of Antihyperglycemic Medications on COVID-19: A Meta-analysis and Systematic Review from Observational Studies |
34% lower mortality (p<0.0001), 35% lower severe cases (p=0.002), and 23% lower hospitalization (p=0.02). Meta analysis of 56 studies showing lower mortality and hospitalization with metformin, GLP-1 receptor agonists, and SGLT-2 inhibitors in COVID-19 patients with type 2 diabetes, while insulin was associated with increased risks. | ||
Apr 29 |
et al., Scientific Reports, doi:10.1038/s41598-024-58532-7 | Cheminformatics approach to identify andrographolide derivatives as dual inhibitors of methyltransferases (nsp14 and nsp16) of SARS-CoV-2 |
In Silico study showing that andrographolide derivatives (PubChem CID 2734589 and 138968421) are potential dual inhibitors of SARS-CoV-2 methyltransferases nsp14 and nsp16, which are crucial for viral replication and evading host immune r.. | ||
Apr 28 |
et al., MDPI AG, doi:10.20944/preprints202404.1825.v1 | In Silico Comparative Analysis of Ivermectin and Nirmatrelvir Inhibitors Interacting with the SARS-CoV-2 Main Protease |
In Silico study showing that ivermectin and nirmatrelvir interact with the SARS-CoV-2 main protease (Mpro). Authors used molecular docking and 100ns molecular dynamics simulations to investigate the binding interactions. Nirmatrelvir form.. | ||
Apr 28 |
et al., International Journal of Immunogenetics, doi:10.1111/iji.12674 | Vitamin D receptor gene polymorphisms role in COVID‐19 severity: Results of a Mexican patients’ cohort |
Retrospective 292 COVID-19 patients finding that haplotype TC of the FokI and TaqI vitamin D receptor (VDR) gene polymorphisms was associated with an increased risk of critical COVID-19. | ||
Apr 27 |
et al., medRxiv, doi:10.1101/2024.04.26.24306354 | Vitamin D, acute respiratory infections, and Covid-19: the curse of small-size randomised trials. A critical review with meta-analysis of randomised trials |
Unregistered meta analysis cherry-picking the ICU outcome and including 9 late treatment RCTs with ICU outcomes for vitamin D. It's unclear why ICU risk would be used when there are more studies reporting mortality which is also less subj.. | ||
Apr 26 |
et al., BMC Pulmonary Medicine, doi:10.1186/s12890-024-03013-w | Retinol and retinol binding protein 4 levels and COVID-19: a Mendelian randomization study |
Mendelian randomization study suggesting a causal association between retinol and related proteins (RBP4, RDH16, CRABP1) and COVID-19. The study found that genetically-predicted higher retinol levels were associated with lower COVID-19.. | ||
Apr 26 |
et al., Journal of Proteins and Proteomics, doi:10.1007/s42485-024-00136-w | Targeting COVID-19 (SARS-CoV-2) main protease through phytochemicals of Albizia lebbeck: molecular docking, molecular dynamics simulation, MM–PBSA free energy calculations, and DFT analysis |
In Silico study showing potential benefits of quercetin and other phytochemicals from Albizia lebbeck as SARS-CoV-2 main protease (Mpro) inhibitors. Using molecular docking, the authors identified four promising compounds: vicenin 2, myri.. | ||
Apr 25 |
et al., BMC Oral Health, doi:10.1186/s12903-024-04246-1 | Oral mouthwashes for asymptomatic to mildly symptomatic adults with COVID-19 and salivary viral load: a randomized, placebo-controlled, open-label clinical trial |
RCT 90 low-risk asymptomatic to mildly symptomatic COVID-19 patients showing no significant difference in salivary viral load with cetylpyridinium chloride or on-demand aqueous chlorine dioxide mouthwash. Both treatments increased Ct valu.. | ||
Apr 24 |
et al., Public Health Nutrition, doi:10.1017/S1368980024000934 | The role of vitamin D in outcomes of critical care in COVID-19 patients: Evidence from an umbrella meta-analysis of interventional and observational studies |
58% lower mortality (p=0.05). Umbrella meta analysis of 13 meta analyses showing significantly lower mortality with vitamin D supplementation, and significantly higher mortality, infection risk, and severity with vitamin D deficiency in COVID-19 patients. Lower vitami.. | ||
Apr 24 |
et al., Viruses, doi:10.3390/v16050665 | Exploring the Antiviral Potential of Esters of Cinnamic Acids with Quercetin |
In Vitro study showing that esters of cinnamic acids with quercetin, particularly ester 7, inhibit SARS-CoV-2 and hCoV-OC43 coronavirus infection in Vero-76 and Vero E6 cells. Mechanism of action studies suggest ester 7 may inhibit corona.. | ||
Apr 23 |
et al., Immunity, Inflammation and Disease, doi:10.1002/iid3.1262 | Comparison of effectiveness and safety of molnupiravir versus sotrovimab for COVID‐19: A systematic review and meta‐analysis |
Meta analysis of 13 studies involving 16,166 patients showing higher mortality and higher incidence of adverse events with molnupiravir compared with sotrovimab. | ||
Apr 22 |
et al., PLOS ONE, doi:10.1371/journal.pone.0300441 | Bioinformatics and system biology approaches to determine the connection of SARS-CoV-2 infection and intrahepatic cholangiocarcinoma |
In Silico study suggesting that quercetin and tetrandrine are potential treatments for COVID-19 and intrahepatic cholangiocarcinoma (ICC). Authors identify 70 shared differentially expressed genes between COVID-19 and ICC, indicating simi.. | ||
Apr 22 |
et al., Viruses, doi:10.3390/v16040647 | Back to the Basics of SARS-CoV-2 Biochemistry: Microvascular Occlusive Glycan Bindings Govern Its Morbidities and Inform Therapeutic Responses |
Review of the biochemical underpinnings of the severe morbidities of COVID-19, focusing on the binding of the SARS-CoV-2 spike protein (SP) to sialylated glycans on host cell surfaces. Authors highlight how the SP attaches particularly ti.. | ||
Apr 20 |
et al., BMC Pulmonary Medicine, doi:10.1186/s12890-024-03001-0 | The role of colchicine in the management of COVID-19: a meta-analysis |
65% lower mortality (p=0.01), 60% lower ventilation (p=0.09), 71% lower ICU admission (p=0.08), and 93% lower need for oxygen therapy (p<0.0001). Systematic review and meta-analysis of 8 studies (4 RCTs) involving 16,488 COVID-19 patients showed significantly lower mortality and need for oxygen therapy with colchicine. | ||
Apr 19 |
et al., Molecular Neurodegeneration, doi:10.1186/s13024-024-00728-6 | Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration |
Review of melatonin as a potential ferroptosis inhibitor for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration. Authors propose that ferroptosis, an iron-dependent cell death triggered by lipid peroxidation, ma.. | ||
Apr 19 |
et al., Melatonin Research, doi:10.32794/mr112500168 | Melatonin and viral infections: A review focusing on therapeutic effects and SARS-CoV-2 |
Review of the potential therapeutic effects of melatonin on viral infections, with a focus on SARS-CoV-2 and COVID-19. Authors highlight melatonin's potent anti-inflammatory, antioxidant, and immunomodulatory properties, which suggest its.. | ||
Apr 18 |
et al., Research Square, doi:10.21203/rs.3.rs-4180797/v1 | The selective effect of Ivermectin on different human coronaviruses; in-vitro study |
In Vitro study showing dose-dependent inhibition of wildtype and omicron SARS-CoV-2 with 0.5-5μM ivermectin. Authors found no significant effect for alphacoronavirus NL63 and a moderate effect for betacoronavirus OC43. In contrast, iverme.. | ||
Apr 17 |
et al., International Immunopharmacology, doi:10.1016/j.intimp.2024.112073 | Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65 |
Mouse study showing that ivermectin improves cardiac function and reduces inflammation in models of viral and autoimmune myocarditis. Authors found that ivermectin inhibited the nuclear translocation of NF-κB/p65 in macrophages by targeti.. | ||
Apr 16 |
et al., PLOS ONE, doi:10.1371/journal.pone.0298201 | In silico study of alkaloids with quercetin nucleus for inhibition of SARS-CoV-2 protease and receptor cell protease |
In Silico study showing that the alkaloids with a quercetin nucleus may inhibit SARS-CoV-2 infection by binding to the main protease (Mpro) and the host cell protease TMPRSS2. Molecular docking analysis found three compounds, Phyllospadin.. | ||
Apr 16 |
et al., ScienceOpen, doi:10.58647/DRUGARXIV.PR000010.v1 | Network-based multi-omics-disease-drug associations reveal drug repurposing candidates for COVID-19 disease phases |
In Silico study identifying potential drugs beneficial for COVID-19 by integrating transcriptomics, proteomics, metabolomics, lipidomics, and drug data. Authors explore interactions between drugs, molecular features, and disease severity... | ||
Apr 13 |
et al., European Journal of Pharmaceutical Sciences, doi:10.1016/j.ejps.2024.106766 | Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: a promising therapeutic and prophylactic treatment for viral respiratory infections |
In Vitro and Ex Vivo study showing that curcumin and quercetin co-encapsulated in nanoemulsions (NEs) for nasal administration inhibited murine β-coronavirus (MHV-3) infection. MHV-3 belongs to the same family as SARS-CoV-2. Authors found.. | ||
Apr 12 |
et al., Journal of Nanobiotechnology, doi:10.1186/s12951-024-02435-2 | Development of nanoparticles incorporated with quercetin and ACE2-membrane as a novel therapy for COVID-19 |
In Vitro study showing that nanoparticles coated with both ACE2-containing cell membranes and quercetin (CM-NP-Q) inhibit SARS-CoV-2 infection in human lung cells. Authors developed nanoparticles incorporated with quercetin (NP-Q), ACE2-c.. | ||
Apr 12 |
et al., Global Journal of Aging & Geriatric Research, doi:10.33552/GJAGR.2024.03.000557 | Early Treatment Outcomes of SARS-Cov-2 with Ivermectin, Nitazoxanide and Acetylsalicylic Acid in 2 Nursing Homes During The COVID-19 Pandemic in Cali, Colombia |
Retrospective 475 nursing home residents showing low mortality with early treatment using ivermectin, nitazoxanide, and acetylsalicylic acid. All residents were treated when the first positive cases were identified. 87 residents tested po.. | ||
Apr 12 |
et al., Infectious Diseases and Therapy, doi:10.1007/s40121-024-00971-w | Effect of Regdanvimab on Mortality in Patients Infected with SARS-CoV-2 Delta Variants: A Propensity Score-Matched Cohort Study |
83% lower mortality (p=0.12), 33% lower ICU admission (p=0.49), and 55% lower need for oxygen therapy (p=0.01). PSM retrospective 378 hospitalized COVID-19 patients in Korea showing lower progression with regdanvimab treatment. | ||
Apr 12 |
et al., medRxiv, doi:10.1101/2024.04.10.24305647 | Incidence and Risk of Post-COVID-19 Thromboembolic Disease and the Impact of Aspirin Prescription; Nationwide Observational Cohort at the US Department of Veteran Affairs. |
46% lower mortality (p=0.001). PSM retrospective 334,374 COVID-19 patients showing decreased risk of venous thromboembolism, including pulmonary embolism and deep vein thrombosis, but increased risk of arterial thromboembolic disorders, including ischemic stroke and ac.. | ||
Apr 7 |
et al., European Journal of Pharmaceutics and Biopharmaceutics, doi:10.1016/j.ejpb.2024.114279 | Throat spray formulated with virucidal Pharmaceutical excipients as an effective early prophylactic or treatment strategy against pharyngitis post-exposure to SARS CoV-2 |
In Silico, In Vitro, and rat study showing potential prophylactic and therapeutic benefits of a curcumin-loaded self-nanoemulsifying drug delivery system throat spray against SARS-CoV-2 infection and pharyngitis. Molecular docking studies.. | ||
Apr 5 |
et al., Current Medicinal Chemistry, doi:10.2174/0109298673292839240329081008 | Discovery of Novel Natural Inhibitors Against SARS-CoV-2 Main Protease: A Rational Approach to Antiviral Therapeutics |
In Silico and In Vitro study showing potential inhibition of SARS-CoV-2 main protease (Mpro) by quercetin and four other natural compounds isolated from medicinal plants. Authors used molecular docking, molecular dynamics simulations, and.. | ||
Apr 5 |
et al., Immunity, Inflammation and Disease, doi:10.1002/iid3.1232 | Nirmatrelvir and ritonavir combination against COVID‐19 caused by omicron BA.2.2 in the elderly: A single‐center large observational study |
PSM retrospective 648 elderly COVID-19 patients showing no significant difference in time to viral clearance with paxlovid. However, in subgroup analysis of patients treated within 10 days of symptom onset, treatment was associated with f.. | ||
Apr 5 |
et al., Неонатологія, хірургія та перинатальна медицина, doi:10.24061/2413-4260.XIV.1.51.2024.6 | Micronutrient status (vitamins A and D) and its effect on the severity of the course of COVID-19 in children |
60% lower severe cases (p=0.13) and 89% fewer cases (p=0.13). Retrospective 112 pediatric COVID-19 patients and 23 healthy controls showing lower levels of vitamins A and D associated with more severe disease. Patients with moderate and severe COVID-19 had significantly lower vitamin A, vitamin D, a.. | ||
Apr 5 |
, T., BioMetals, doi:10.1007/s10534-024-00590-5 | Coordination chemistry suggests that independently observed benefits of metformin and Zn2+ against COVID-19 are not independent |
In Silico analysis suggesting potential benefits of metformin and zinc for COVID-19. Author proposes that metformin can form a complex with zinc ions, increasing zinc bioavailability, and that the metformin-zinc complex may slow viral mul.. | ||
Apr 5 |
et al., Pharmaceuticals, doi:10.3390/ph17040463 | Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients |
RCT of 33 long COVID outpatients showing anti-inflammatory and anti-fatigue effects with treatment based on Echinacea angustifolia, rosehip, propolis, royal jelly, and zinc. The treatment significantly reduced inflammatory biomarkers like.. | ||
Apr 5 |
et al., Research Square, doi:10.21203/rs.3.rs-4090027/v1 | Course of inflammation and infection markers differ in ICU patients with severe COVID-19 under casirivimab- and/or tocilizumab application: an observational study |
16% higher mortality (p=0.8). Retrospective 95 ICU patients showing no significant difference in mortality with casirivimab/imdevimab. There was significantly higher mortality with tocilizumab. | ||
Apr 4 |
et al., Scientific Reports, doi:10.1038/s41598-024-57726-3 | The metabolic footprint of Vero E6 cells highlights the key metabolic routes associated with SARS-CoV-2 infection and response to drug combinations |
In Vitro study showing that remdesivir and azithromycin, either alone or in combination, can modify the glycolic-gluconeogenesis pathway in host cells, inhibiting the mitochondrial oxidative damage caused by SARS-CoV-2. Authors use Nuclea.. | ||
Apr 4 |
et al., Pharmacology Research & Perspectives, doi:10.1002/prp2.1194 | Ursodeoxycholic acid may protect from severe acute respiratory syndrome coronavirus 2 Omicron variant by reducing angiotensin‐converting enzyme 2 |
Syrian hamster study showing ursodeoxycholic acid (UDCA) may protect against SARS-CoV-2 omicron variant transmission and infection. Hamsters treated prophylactically with oral UDCA had significantly less weight loss compared to untreated .. | ||
Apr 4 |
et al., New England Journal of Medicine, doi:10.1056/NEJMoa2309003 | Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19 |
Delayed publication for EPIC-SR showing no significant difference in time to sustained alleviation. Selected results were first made available in December 2021 [Pfizer]. | ||
Apr 4 |
et al., NCT04344184 | SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI) |
19% lower mortality (p=0.75) and 2% worse results (p=0.28). RCT 47 ICU patients showing no significant differences with vitamin C treatment. | ||
Apr 3 |
et al., Dentistry Journal, doi:10.3390/dj12040093 | The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults |
Randomized study showing that rinsing with Coca-Cola significantly lowered salivary pH, with an average of 27 minutes to return to baseline, and rinsing with tested oral care products or water after exposure increased the minimum salivary.. | ||
Apr 3 |
et al., Antimicrobial Agents and Chemotherapy, doi:10.1128/aac.01015-23 | Two-way pharmacodynamic modeling of drug combinations and its application to pairs of repurposed Ebola and SARS-CoV-2 agents |
In Silico study supporting the synergistic combination of nitazoxanide and remdesivir for SARS-CoV-2. Authors developed a two-way pharmacodynamic modeling approach to capture the concentration-dependent drug-drug interactions and combined.. | ||
Apr 2 |
et al., bioRxiv, doi:10.1101/2024.04.01.587566 | Distal Protein-Protein Interactions Contribute to SARS-CoV-2 Main Protease Substrate Binding and Nirmatrelvir Resistance |
In Vitro and crystallographic study reveals that the L50F mutation in SARS-CoV-2 main protease (Mpro) can restore the reduced enzymatic activity caused by nirmatrelvir resistance mutations E166A/L167F through enhanced protein-protein inte.. | ||
Apr 1 |
et al., Research Square, doi:10.21203/rs.3.rs-4157424/v1 | Azvudine reduces the mortality rate of patients with Coronavirus disease 2019: a single-center retrospective analysis study |
35% lower mortality (p=0.05). Retrospective 2,862 hospitalized COVID-19 patients in China showing lower mortality with azvudine treatment. |
We aim to cover the most promising early treatments for
COVID-19. We use pre-specified effect extraction criteria that prioritizes
more serious outcomes, for details see methods. For specific
outcomes and different treatment stages see the individual pages. Not all
treatments are covered here, effectiveness has been reported for many other treatments in studies.
Of the 4,131 studies,
2,164 present results comparing with a control group,
1,968 are treatment studies, and
196 analyze outcomes based on serum levels. There are
67 animal studies,
143 in silico studies,
237 in vitro studies,
257 reviews,
and 175 meta analyses.
Please send us corrections, updates, or comments.
c19early involves the extraction of 100,000+ datapoints from
thousands of papers. Community updates
help ensure high accuracy.
Treatments and other interventions are complementary.
All practical, effective, and safe
means should be used based on risk/benefit analysis.
No treatment or intervention is 100% available and effective for all current
and future variants.
We do not provide medical advice. Before taking any medication,
consult a qualified physician who can provide personalized advice and details
of risks and benefits based on your medical history and situation. FLCCC and WCH
provide treatment protocols.
Thanks for your feedback! Please search before submitting papers and note
that studies are listed under the date they were first available, which may be
the date of an earlier preprint.